N° 05
For patients
Axon Revive™
What if we looked beyond managing the symptoms of diabetic neuropathy?
Burning. Tingling. Numbness. Pain. Loss of sensation. Difficulty walking. Problems with balance. Reducing the pain is not the same as repairing the biological environment around the nerve.
It isn't simply a problem with pain signals.
Diabetic peripheral neuropathy involves both the nerve and the biological environment supporting it. Over time, chronic high blood sugar and other metabolic changes can contribute to:
- Oxidative stress
- Endothelial dysfunction
- Microvascular injury
- Reduced nerve perfusion
- Inflammation
- Mitochondrial dysfunction
- Advanced glycation end products (AGEs)
- Progressive axonal injury
The tiny blood vessels supplying your nerves matter. As the microvascular environment deteriorates, blood flow and oxygen delivery can become impaired. Nerves need blood flow, oxygen, nutrients, and energy to function and repair.
Traditional treatment has an important role. But it leaves a gap.
Medications such as gabapentin (Neurontin), pregabalin (Lyrica), duloxetine (Cymbalta), and others can reduce pain and improve quality of life. Good diabetes management (blood sugar, blood pressure, lipids, weight) remains essential too.
But once significant neuropathy has developed, medicine has had limited options for actually restoring damaged nerve function. That is the gap we became interested in. Instead of only asking "How can we decrease neuropathy pain?", we asked:
Can we improve the biological environment surrounding the damaged nerve?
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The idea behind Axon Revive™
Several biological targets, not a single medication or procedure.
For more than three years we have been exploring this approach to diabetic peripheral neuropathy.
Support the microvascular environment
Peripheral nerves are fed by tiny vessels called the vasa nervorum, which diabetes can damage. One objective is to stimulate the local tissue in ways intended to support vascular remodeling and blood flow.
Address oxidative stress
Chronic high blood sugar increases reactive oxygen species. Oxidative stress is implicated in endothelial dysfunction, mitochondrial damage, inflammation, and progressive nerve dysfunction, so the metabolic and oxidative environment is part of the protocol.
Stimulate a local healing response
The protocol includes acoustic wave therapy, which delivers mechanical energy to tissue and is being investigated for effects on local circulation, cellular signaling, angiogenic pathways, and tissue repair.
Use your own platelets
High-concentration PRP, made from your own blood, is placed around specific nerves under ultrasound guidance. The goal isn’t simply to make the nerve stop hurting. It’s to create a biological environment that may better support it.
What a course of care can include.
Axon Revive isn't simply PRP for neuropathy, and it isn't one treatment on one afternoon. It's a structured protocol designed around the biology of diabetic neuropathy.
Nerves don't heal overnight. Patients are followed over weeks and months as pain, sensation, medication use, sleep, balance, and function are assessed.
- Metabolic optimization
- Strategies aimed at reducing oxidative stress
- Acoustic wave therapy
- Vascular and tissue stimulation
- High-concentration PRP
- Ultrasound-guided perineural treatment
- Continued metabolic and biological support
- Follow-up as the nerve responds over time
Encouraging early clinical experience.
Axon Revive grew out of about three years of clinical experience. In our initial experience, approximately 80–85% of treated patients reported meaningful improvement. Among responders we observed reports of:
- Reduced neuropathic pain
- Reduced reliance on neuropathy medications
- Some patients discontinuing neuropathy medications under medical supervision
- Improved sensation
- Improved walking ability
- Improved balance
- Improved sleep as symptoms decrease
Important
Early clinical experience. Not a trial. Not a cure.
Important. These results represent our early clinical experience, not evidence from a randomized, placebo-controlled clinical trial. Axon Revive should not be interpreted as a proven cure for diabetic peripheral neuropathy, and individual outcomes vary.
Find an Axon Revive™ provider.
Axon Revive providers are beginning to practice across the United States. Our provider directory lists physicians and qualified medical providers who have completed Axon Revive training.
The public provider directory is launching soon. Leave your details and we'll let you know as soon as providers near you are listed.
Don't just think about the symptom.
Think about the biology behind it.
Understand the nerve. Understand the blood supply. Understand the metabolic environment. Then ask what we can do to change it.
Educational information only; not medical advice. Talk with your physician about whether any treatment is appropriate for you.